Vertebrate Smoothened functions at the primary cilium

被引：0
|
作者：
Kevin C. Corbit
Pia Aanstad
Veena Singla
Andrew R. Norman
Didier Y. R. Stainier
Jeremy F. Reiter
机构：
[1] Developmental and Stem Cell Biology Program,Department of Biochemistry and Biophysics
[2] Diabetes Center,undefined
[3] University of California,undefined
来源：
Nature | 2005年 / 437卷
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摘要：
The primary cilium is a mysterious organelle found on vertebrate cells in the interphase, the point in the cell cycle between two cell divisions when DNA is replicated and individual chromosomes are not distinguishable. The discovery that Smoothened, part of the Hedgehog signalling pathway, functions at the primary cilium supports the theory that the cilium acts as an antenna through which various signals are sensed and transduced. These signals may play an important role in development and disease.
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页码：1018 / 1021
页数：3
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