Role of Drug – Drug Interactions in the Efficacy and Safety of Clarithromycin Treatment for Helicobacter Pylori Eradication

被引：0

作者：

S. Yu. Serebrova

E. N. Kareva

N. N. Eremenko

A. B. Prokof’ev

D. O. Kurguzova

V. N. Drozdov

N. B. Lazareva

I. A. Komissarenko

A. K. Starodubtsev

机构：

[1] Scientific Center for Expert Evaluation of Medicinal Products,

[2] Ministry of Health of the Russian Federation,undefined

[3] I. M. Sechenov First Moscow State Medical University (Sechenov University),undefined

[4] N. I. Pirogov National Research Medical University,undefined

[5] A. I. Evdokimov Moscow State University of Medicine and Dentistry,undefined

来源：

Pharmaceutical Chemistry Journal | 2019年 / 53卷

关键词：

clarithromycin; drug resistance; adverse drug reactions; drug – drug interactions;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Current risks from resistance, adverse drug reactions, and drug – drug interactions of clarithromycin used as a component of Helicobacter pylori eradication therapy are reviewed. The acid sensitivity of clarithromycin i responsible for the dependence of its pharmacological properties on the efficacy of proton-pump inhibitors, which could be one reason for the resistance of H. pylori to the macrolide. The potential for clarithromycin drug – drug interactions is related to its metabolism by CYP3A4 and strong inhibition of this enzyme.

引用

页码：678 / 679

页数：1

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