The total large-scale synthesis of a natural toxin argiopine, a polymethylenepolyamine derivative, was developed. It consisted of 26 stages and included three key block schemes. Most of the stages proceeded quantitatively, which excluded the necessity of using the chromatographic separation of intermediates.
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SC Microsin SRL, Bucharest 032364, Romania
Univ Politehn Bucuresti, Dept Sci & Engn Oxide Mat & Nanomat, Bucharest 011061, RomaniaUniv Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, Romania
Maximov, Maxim
Maximov, Oana-Cristina
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SC Microsin SRL, Bucharest 032364, RomaniaUniv Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, Romania
Maximov, Oana-Cristina
Popescu, Codruta C.
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Univ Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, Romania
Univ Bucharest, Fac Chem, Dept Inorgan & Organ Chem, Biochem & Catalysis, RO-050663 Bucharest, RomaniaUniv Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, Romania
Popescu, Codruta C.
Sandu, Nicoleta
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Univ Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, RomaniaUniv Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, Romania
Sandu, Nicoleta
Florea, Mihaela
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Univ Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, Romania
Natl Inst Mat Phys, Magurele 077125, RomaniaUniv Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, Romania
Florea, Mihaela
Mirea, Anca G.
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Natl Inst Mat Phys, Magurele 077125, RomaniaUniv Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, Romania
Mirea, Anca G.
Garbea, Cristian
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SC Microsin SRL, Bucharest 032364, RomaniaUniv Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, Romania
Garbea, Cristian
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Matache, Mihaela
Funeriu, Daniel P.
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Univ Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, RomaniaUniv Bucharest, Res Ctr Appl Organ Chem, RO-050663 Bucharest, Romania