WR-2721 reduces intestinal toxicity from concurrent gemcitabine and radiation treatment

被引：0
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作者：
Thinh P. Phan
Christopher H. Crane
Nora A. Janjan
Eduord Vrdoljak
Luka Milas
Kathy A. Mason
机构：
[1] The University of Texas M.D. Anderson Cancer Center,Department of Experimental Radiation Oncology
[2] The University of Texas M.D. Anderson Cancer Center,Department of Radiation Oncology
[3] University of Split School of Medicine,Center of Oncology and Radiotherapy
[4] Clinic Hospital,undefined
来源：
International Journal of Pancreatology | 2001年 / 29卷
关键词：
Gemcitabine; WR-2721 (amifostine); radiation damage; radioprotector; pancreatic cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background. The nucleoside analog gemcitabine is a potent radiosensitizer of both tumor and normal mucosa, so severe toxic reactions have resulted from its combination with radiation in some clinical treatment schedules for pancreatic cancer. WR-2721 (amifostine) has been shown to reduce normal tissue toxicity produced from both radiation treatment and some chemotherapeutics. The aim of this study was to determine if WR-2721 can protect the gastrointestinal mucosa from injury by concurrent gemcitabine and radiation treatment.
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页码：19 / 23
页数：4
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