Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma

被引：0
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作者：
Alexandre Bozec
Marius Ilie
Olivier Dassonville
Elodie Long
Gilles Poissonnet
José Santini
Emmanuel Chamorey
Marc Ettaiche
Damien Chauvière
Frédéric Peyrade
Christophe Hebert
Karen Benezery
Anne Sudaka
Juliette Haudebourg
Eric Selva
Paul Hofman
机构：
[1] Institut Universitaire de la Face et du Cou,Department of Surgery
[2] IRCAN Inserm U1081 Team 3,Faculty of Medicine
[3] Pasteur Hospital,Laboratory of Clinical and Experimental Pathology
[4] Pasteur Hospital,Human Biobank
[5] Antoine Lacassagne Centre,Department of Statistics
[6] Antoine Lacassagne Centre,Department of Medical Oncology
[7] Antoine Lacassagne Centre,Department of Radiotherapy
[8] Antoine Lacassagne Centre,Department of Pathology
来源：
European Archives of Oto-Rhino-Laryngology | 2013年 / 270卷
关键词：
Head and neck squamous cell carcinoma; Oral cavity; Oropharynx; Circulating tumor cells; CellSearch system;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The objective of this study was to evaluate the potential detection of circulating tumor cells (CTCs) using the CellSearch (CS) Assay™ in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) and then to identify the clinical factors predictive of the presence of CTCs. The presence and number of CTCs were determined using the CS system before treatment, and in 10 healthy individuals (control group). The CS system was able to successfully identify the presence of CTCs in 8 of 49 patients (16 %) before therapy. No CTC was found in the control group. CTCs were detected before therapy in 1 of 19 patients (5 %) with N0 tumor and in 7 of 30 patients (23 %) with N1-2c tumor (p = 0.12; Fisher’s exact test). CTCs were identified in a relatively low proportion of patients with locally advanced HNSCC.
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页码：2745 / 2749
页数：4
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