Diagnostic accuracy of cytology for the detection of endometrial cancer in urine and vaginal samples

被引:0
|
作者
Helena O’Flynn
Neil A. J. Ryan
Nadira Narine
David Shelton
Durgesh Rana
Emma J. Crosbie
机构
[1] University of Manchester,Gynaecological Oncology Research Group, Division of Cancer Sciences, Faculty of Biology, Medicine and Health
[2] St Mary’s Hospital,Division of Gynaecology, St Mary’s Hospital, Manchester University NHS Foundation Trust
[3] Manchester Cytology Centre,undefined
[4] Manchester University NHS Foundation Trust,undefined
[5] Manchester Academic Health Science Centre,undefined
来源
Nature Communications | / 12卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Postmenopausal bleeding triggers urgent investigation by sequential invasive tests that are avoidable for the 90–95% of women who do not have endometrial cancer. A simple, non-invasive tool that accurately identifies cancer and safely reassures healthy women could transform patient care. Here we report, in a cross-sectional diagnostic accuracy study of 103 women with known cancer and 113 with unexplained postmenopausal bleeding, that urine and vaginal cytology has a combined sensitivity of 91.7% (95% CI 85.0%, 96.1%) and specificity of 88.8% (81.2%, 94.1%) for gynecological cancer detection. Cytology identifies 91 endometrial, two fallopian tube and one cervical cancer from 103 known cancer cases. In women with unexplained postmenopausal bleeding, cytology identifies all four endometrial cancers and three others (cervical, ovarian and bladder), for a 12/107 (11.2%) false positive rate. We show proof-of-principle that endometrial cancer can be detected in urine and vaginal fluid. Prospective validation of these findings will support incorporation of this non-invasive test into clinical practice.
引用
收藏
相关论文
共 50 条
  • [1] Diagnostic accuracy of cytology for the detection of endometrial cancer in urine and vaginal samples
    O'Flynn, Helena
    Ryan, Neil A. J.
    Narine, Nadira
    Shelton, David
    Rana, Durgesh
    Crosbie, Emma J.
    NATURE COMMUNICATIONS, 2021, 12 (01)
  • [2] DEveloping Tests for Endometrial Cancer deTection (DETECT): protocol for a diagnostic accuracy study of urine and vaginal samples for the detection of endometrial cancer by cytology in women with postmenopausal bleeding
    Jones, Eleanor R.
    Carter, Suzanne
    O'Flynn, Helena
    Njoku, Kelechi
    Barr, Chloe E.
    Narine, Nadira
    Shelton, David
    Rana, Durgesh
    Crosbie, Emma J.
    BMJ OPEN, 2021, 11 (07):
  • [3] Urine and vaginal cytology for endometrial cancer detection in symptomatic women
    Jones, Eleanor
    Narine, Nadira
    O'Flynn, Helena
    Barr, Chloe
    Njoku, Kelechi
    Carter, Suzanne
    Cornwall, Lisa
    Vinay, Sylvia
    Fullwood, Catherine
    Shelton, David
    Rana, Durgesh
    Crosbie, Emma
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2022, 129 : 39 - 40
  • [4] DIAGNOSTIC ACCURACY OF LIQUID-BASED ENDOMETRIAL CYTOLOGY IN ENDOMETRIAL CANCER DETECTION
    Sorbi, F.
    Fambrini, M.
    Sisti, G.
    Pieralli, A.
    Guaschino, S.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2013, 23 (08)
  • [5] AN AUDIT OF DIAGNOSTIC ACCURACY OF URINE CYTOLOGY IN BLADDER CANCER
    Singh, M.
    Salman, W.
    ACTA CYTOLOGICA, 2010, 54 (03) : 521 - 521
  • [6] THE DIAGNOSTIC-ACCURACY OF ENDOMETRIAL CYTOLOGY WITH PREVICAL
    BACHET, W
    BRUNNER, P
    DODENHOFT, JDJ
    STROBEL, E
    GEBURTSHILFE UND FRAUENHEILKUNDE, 1983, 43 (01) : 11 - 14
  • [7] THE DIAGNOSTIC-ACCURACY OF SPUTUM AND URINE CYTOLOGY
    KERN, WH
    ACTA CYTOLOGICA, 1988, 32 (05) : 651 - 654
  • [8] Endometrial Cytology in Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis of Diagnostic Accuracy
    Wang, Ting
    Jiang, Ruoan
    Yao, Yingsha
    Wang, Yaping
    Liu, Wu
    Qian, Linhua
    Li, Juanqing
    Weimer, Joerg
    Huang, Xiufeng
    JOURNAL OF CLINICAL MEDICINE, 2023, 12 (06)
  • [9] VAGINAL CYTOLOGY IN CANCER DETECTION
    HEDBERG, GT
    NORDISK MEDICIN, 1954, 52 (42) : 1439 - 1441
  • [10] DIAGNOSTIC VALUE OF CYTOLOGY IN ENDOMETRIAL CANCER
    LOPEZGARCIA, N
    CALVODEMORA, S
    ARCOSDELAPLAZA, MD
    LOPEZDELAOSA, L
    CALERO, F
    BARCO, J
    MARCOS, C
    TUBIO, J
    ARCHIVES D ANATOMIE ET DE CYTOLOGIE PATHOLOGIQUES, 1976, 24 (05): : 335 - 338