Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

被引：0

作者：

Nitai C Hait

Laura E Wise

Jeremy C Allegood

Megan O'Brien

Dorit Avni

Thomas M Reeves

Pamela E Knapp

Junyan Lu

Cheng Luo

Michael F Miles

Sheldon Milstien

Aron H Lichtman

Sarah Spiegel

机构：

[1] Virginia Commonwealth University School of Medicine,Department of Biochemistry and Molecular Biology

[2] Massey Cancer Center,Department of Pharmacology and Toxicology

[3] Virginia Commonwealth University School of Medicine,Department of Anatomy and Neurobiology

[4] Virginia Commonwealth University School of Medicine,undefined

[5] Virginia Commonwealth University School of Medicine,undefined

[6] State Key Laboratory of Drug Research,undefined

[7] Shanghai Institute of Materia Medica,undefined

[8] Chinese Academy of Sciences,undefined

来源：

Nature Neuroscience | 2014年 / 17卷

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学科分类号：

摘要：

Fingolimod is a sphingosine-1 phosphate (S1P) receptor modulator and an immune modulator in use as a treatment for the remitting-relapsing form of multiple sclerosis. Hait et al. show that the active form of fingolimod can inhibit neuronal class I histone deacetylases (HDACs), modulate gene expression in the brain and facilitate memory extinction. The authors also show spatial and associative memory deficits in mutant mice lacking the enzyme necessary for formation of the active form of fingolimod.

引用

页码：971 / 980

页数：9

共 34 条

[1] Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory
Hait, Nitai C.
Wise, Laura E.
Allegood, Jeremy C.
O'Brien, Megan
Avni, Dorit
Reeves, Thomas M.
Knapp, Pamela E.
Lu, Junyan
Luo, Cheng
Miles, Michael F.
Milstien, Sheldon
Lichtman, Aron H.
Spiegel, Sarah
NATURE NEUROSCIENCE, 2014, 17 (07) : 971 - 980
[2] Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction
Lattal, K. Matthew
Barrett, Ruth M.
Wood, Marcelo A.
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[3] Inhibition of Histone Deacetylases Facilitates Extinction and Attenuates Reinstatement of Nicotine Self-Administration in Rats
Castino, Matthew R.
Cornish, Jennifer L.
Clemens, Kelly J.
PLOS ONE, 2015, 10 (04):
[4] Infralimbic activity during REM sleep facilitates fear extinction memory
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CURRENT BIOLOGY, 2024, 34 (10) : 2247 - 2255.e5
[5] Oxytocin in dorsal hippocampus facilitates auditory fear memory extinction in rats
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NEUROPHARMACOLOGY, 2022, 202
[6] Systemic administration of riluzole enhances recognition memory and facilitates extinction of fear memory in rats
Sugiyama, Azusa
Saitoh, Akiyoshi
Inagaki, Masatoshi
Oka, Jun-Ichiro
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NEUROPHARMACOLOGY, 2015, 97 : 322 - 328
[7] Spaced conditioned stimulus presentation facilitates the extinction of strong fear memory in mice
Kawakami, Chinatsu
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Sakaguchi, Masanori
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 718
[8] Pharmacological enhancement of mGluR5 facilitates contextual fear memory extinction
Sethna, Ferzin
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LEARNING & MEMORY, 2014, 21 (12) : 647 - 650
[9] Hippocampal HECT E3 ligase inhibition facilitates consolidation, retrieval, and reconsolidation, and inhibits extinction of contextual fear memory
Redondo, Jadier
Popik, Bruno
Casagrande, Mirelle
Silva, Mateus Oliveira
Quillfeldt, Jorge Alberto
Alvares, Lucas de Oliveira
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NEUROBIOLOGY OF LEARNING AND MEMORY, 2020, 167
[10] Transgenic inhibition of neuronal calcineurin activity in the forebrain facilitates fear conditioning, but inhibits the extinction of contextual fear memories
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Nijholt, Ingrid M.
Visser, Anniek K. D.
Eisel, Ulrich L. M.
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NEUROBIOLOGY OF LEARNING AND MEMORY, 2008, 89 (04) : 595 - 598

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