Isolation of cytochrome P450 3A (CYP3A) inhibitors from Hyuganatsu, Citrus tamurana Hort.

被引：0
|
作者：
Shinzo Hosoi
Eri Shimizu
Noriyuki Usami
Ikuo Yamamoto
Kazuhiko Arimori
Manabu Okumura
Muneaki Hidaka
Mitsuko Yamada
Akiyo Sakushima
机构：
[1] Kyushu University of Health and Welfare,School of Pharmaceutical Sciences
[2] Miyazaki Medical College Hospital,Department of Pharmacy
[3] Minami Kyushu University,Department of Nutrition Science, Faculty of Health and Nutrition Sciences
来源：
Journal of Natural Medicines | 2006年 / 60卷
关键词：
CYP 3A; Hyuganatsu; Limonoid; Enzyme inhibitor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study was conducted to identify cytochrome P450 3A (CYP3A) inhibitory components of Hyuganatsu, Citrus tamurana Hort., by investigating the effects on midazolam 1′-hydroxylase activity of human liver microsomes. As a consequence, limonin and nomilin were identified as CYP3A inhibitors from the endocarp of Hyuganatsu.
引用
收藏
页码：240 / 242
页数：2
相关论文
共 50 条
  • [1] Isolation of cytochrome P450 3A (CYP3A) inhibitors from Hyuganatsu, Citrus tamurana Hort.
    Hosoi, Shinzo
    Shimizu, Eri
    Usami, Noriyuki
    Yamamoto, Ikuo
    Arimori, Kazuhiko
    Okumura, Manabu
    Hidaka, Muneaki
    Yamada, Mitsuko
    Sakushima, Akiyo
    JOURNAL OF NATURAL MEDICINES, 2006, 60 (03) : 240 - 242
  • [2] Inhibitory effects of citrus fruits on cytochrome P450 3A (CYP3A) activity in humans
    Fujita, K
    Hidaka, M
    Takamura, N
    Yamasaki, K
    Iwakiri, T
    Okumura, M
    Kodama, H
    Yamaguchi, M
    Ikenoue, T
    Arimori, K
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2003, 26 (09) : 1371 - 1373
  • [3] Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs
    Flentge, Charles A.
    Randolph, John T.
    Huang, Peggy P.
    Klein, Larry L.
    Marsh, Kennan C.
    Harlan, John E.
    Kempf, Dale J.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (18) : 5444 - 5448
  • [4] Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle
    Mery Giantin
    Minna Rahnasto-Rilla
    Roberta Tolosi
    Lorena Lucatello
    Marianna Pauletto
    Giorgia Guerra
    Francesca Pezzato
    Rosa M. Lopparelli
    Roberta Merlanti
    Paolo Carnier
    Francesca Capolongo
    Paavo Honkakoski
    Mauro Dacasto
    Scientific Reports, 9
  • [5] Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle
    Giantin, Mery
    Rahnasto-Rilla, Minna
    Tolosi, Roberta
    Lucatello, Lorena
    Pauletto, Marianna
    Guerra, Giorgia
    Pezzato, Francesca
    Lopparelli, Rosa M.
    Merlanti, Roberta
    Carnier, Paolo
    Capolongo, Francesca
    Honkakoski, Paavo
    Dacasto, Mauro
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [6] REGULATION OF HEPATIC CYTOCHROME P450 3A (CYP3A) ACTIVITY BY MICRORNAS (MIRNAS)
    Vuppalanchi, Raj
    Goswami, Chirayu P.
    Nalamasu, Rohit
    Muralidharan, Sriya
    Liang Tiebing
    Bell, Lauren N.
    Jones, David R.
    Li, Lang
    Chalasani, Naga P.
    HEPATOLOGY, 2011, 54 : 718A - 718A
  • [7] Use of midazolam urinary metabolic ratios for cytochrome P450 3A (CYP3A) phenotyping
    Streetman, DS
    Kashuba, ADM
    Bertino, JS
    Kulawy, R
    Rocci, ML
    Nafziger, AN
    PHARMACOGENETICS, 2001, 11 (04): : 349 - 355
  • [8] Effect of classic and atypical neuroleptics on cytochrome P450 3A (CYP3A) in rat liver
    Jacek Wójcikowski
    Anna Haduch
    Władysława A. Daniel
    Pharmacological Reports, 2012, 64 : 1411 - 1418
  • [9] Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity
    Hidaka, M
    Fujita, K
    Ogikubo, T
    Yamasaki, K
    Iwakiri, T
    Okumura, M
    Kodama, H
    Arimori, K
    DRUG METABOLISM AND DISPOSITION, 2004, 32 (06) : 581 - 583
  • [10] Mechanism-based inactivation of cytochrome P450 3A (CYP3A) by HIV protease inhibitors (PI's)
    Ernest, CS
    Hall, SD
    Jones, DR
    DRUG METABOLISM REVIEWS, 2003, 35 : 170 - 170
12345