CUL4B ubiquitin ligase in mouse development: A model for human X-linked mental retardation syndrome?

被引：0
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作者：
Yongchao Zhao
Yi Sun
机构：
[1] University of Michigan,Division of Radiation and Cancer Biology, Department of Radiation Oncology
来源：
Cell Research | 2012年 / 22卷
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摘要：
CUL4B, a member of the cullin-RING ubiquitin ligase family, is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al. showed that Cul4b plays an essential developmental role in the extra-embryonic tissues, while it is dispensable in the embryo proper during mouse embryogenesis. Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients.
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页码：1224 / 1226
页数：2
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