The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain

被引：0
|
作者：
Rachel E. Miller
Phuong B. Tran
Alia M Obeidat
Padmanabhan Raghu
Shingo Ishihara
Richard J. Miller
Anne-Marie Malfait
机构：
[1] Rush University Medical Center,Department of Internal Medicine, Division of Rheumatology
[2] Rush University Medical Center,Department of Biochemistry
[3] Northwestern University,Department of Pharmacology
来源：
Current Osteoporosis Reports | 2015年 / 13卷
关键词：
Osteoarthritis; Pain; Sensitization; Animal models; Nerve growth factor; Sodium channels;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies have provided novel insights into the mechanisms that drive the pain associated with joint destruction. In this narrative review, we describe current knowledge regarding the changes in the peripheral and central nervous systems that occur during the progression of osteoarthritis and discuss how therapeutic interventions may provide pain relief.
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页码：318 / 326
页数：8
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