Multiple sclerosis. New therapeutic strategies in the experimental stage [Multiple Sklerose. Neue therapeutische Strategien im experimentellen Stadium]

被引：0
|
作者：
Zipp F. [1 ,2 ]
Sommer N. [1 ]
Rösener M. [1 ]
Dichgans J. [1 ]
Martin R. [1 ]
机构：
[1] Neurologische Universitätsklinik, Tübingen
[2] Neurologische Klinik, Eberhard-Karls-Universität Tübingen, D-72076 Tübingen
来源：
Der Nervenarzt | 1997年 / 68卷 / 2期
关键词：
immunopathogenesis; multiple sclerosis; therapy;
D O I：
10.1007/s001150050103
中图分类号：
学科分类号：
摘要：
Extensive research in the field of multiple sclerosis (MS) has lead to a preliminary pathogenetic concept without solving the etiopathogenesis. According to animal experiments and human in vitro studies MS is a T cell-mediated autoimmune disease. Experimental therapeutical strategies are aiming at the inhibition of T cell activation, transmigration through the blood brain barrier and local inflammation and demyelination. Several substances are already being tested in clinical studies with magnetic resonance imaging as a tool to quantify inflammatory lesions and to shorten the study course. This review will give a summary about actual experimental therapies resulting from the current pathogenetic concept.
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页码：94 / 101
页数：7
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