Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis

被引：0

作者：

Sophie L. M. Walker

Chand Muthoo

Jenifer Sanchez

Ana Gutierrez Del Arroyo

Gareth L. Ackland

机构：

[1] Queen Mary University of London,Translational Medicine and Therapeutics, William Harvey Research Institute

来源：

Intensive Care Medicine Experimental | / 10卷

关键词：

Sepsis; Gender; Leukocyte; Cardiac dysfunction;

D O I：

暂无

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学科分类号：

摘要：

Sex differences in sepsis are underexplored, even though female sex appears to be cardioprotective in early sepsis.In early normovolaemic polymicrobial sepsis, hyperdynamic response occurs in males, whereas myocardial stress/injury is limited in females, in part mediated by less cardiac infiltration of CD4 + leukocytes and independent of shedding of TNFα from peripheral circulating leukocytes.

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