Synthesis, Anticancer Evaluation, and Molecular Docking Study of 1,2,3-Triazole-Containing Hydrazones as Potential HER2 Kinase Inhibitors

被引：1

作者：

Das, V. B. ^{[1
]}

Poojary, B. ^{[1
]}

Kamat, V. ^{[2
]}

Hamzad, S. ^{[3
]}

Suman, P. ^{[4
]}

机构：

[1] Mangalore Univ, Dept Chem, Mangaluru 574199, Karnataka, India

[2] Jain Univ, Ctr Nano & Mat Sci, Jain Global Campus, Bengaluru 562112, Karnataka, India

[3] Jain Univ, Fac Engn & Technol, Dept Chem, Ramanagara 562112, Karnataka, India

[4] Cent Univ Punjab, Dept Human Genet & Mol Med, Bathinda 151401, Punjab, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 03期

关键词：

1,3-dipolar cycloaddition reaction; 1,2,3-triazoles; hydrazones; MCF-7; anticancer activity; molecular docking; BIOLOGICAL EVALUATION; CLICK CHEMISTRY; DISCOVERY; DESIGN;

D O I：

10.1134/S1070428024030199

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of 1,2,3-triazole-containing hydrazones have been synthesized via Cu(I)-mediated 1,3-dipolar cycloaddition reaction. The structures of the synthesized compounds were elucidated by NMR, mass spectrometry, and IR spectroscopy. The synthesized compounds were screened for their cytotoxicity by MTT assay against MCF-7 cancer cell line, and a number of derivatives showed good anticancer potential. In silico molecular docking study revealed good binding affinity of the synthesized compounds for the target HER2 kinase domain complexed with TAK-285 (PDB ID: 3RCD).

引用

页码：502 / 512

页数：11

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