Microarray-based genomic selection for high-throughput resequencing

被引：0
|
作者：
David T Okou
Karyn Meltz Steinberg
Christina Middle
David J Cutler
Thomas J Albert
Michael E Zwick
机构：
[1] Emory University School of Medicine,Department of Human Genetics
[2] Program in Population Biology,undefined
[3] Ecology and Evolution,undefined
[4] Emory University,undefined
[5] NimbleGen Systems,undefined
[6] Inc.,undefined
[7] 1 Science Court,undefined
来源：
Nature Methods | 2007年 / 4卷
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摘要：
We developed a general method, microarray-based genomic selection (MGS), capable of selecting and enriching targeted sequences from complex eukaryotic genomes without the repeat blocking steps necessary for bacterial artificial chromosome (BAC)-based genomic selection. We demonstrate that large human genomic regions, on the order of hundreds of kilobases, can be enriched and resequenced with resequencing arrays. MGS, when combined with a next-generation resequencing technology, can enable large-scale resequencing in single-investigator laboratories.
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页码：907 / 909
页数：2
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