Intravenous Immunoglobulin: An Update on the Clinical Use and Mechanisms of Action

被引：0

作者：

VIR-SINGH NEGI

SRIRAMULU ELLURU

SOPHIE SIBÉRIL

STÉPHANIE GRAFF-DUBOIS

LUC MOUTHON

MICHEL D. KAZATCHKINE

SÉBASTIEN LACROIX-DESMAZES

JAGADEESH BAYRY

SRINI V. KAVERI

机构：

[1] Université Pierre et Marie Curie (UPMC Paris-6) and Equipe 16-Immuno-pathology and Therapeutic Intervention,INSERM UMRS 872, Université René Descartes (Paris

[2] Centre de Recherche des Cordeliers,5)

[3] Université de Technologie,Department of Medicine

[4] Jawaharlal Institute of Postgraduate Medical Education and Research,Service de Médecine Interne

[5] Centre de Référence pour les vascularites et la sclérodermie systémique,INSERM UMRS 872

[6] Assistance Publique-Hôpitaux de Paris,undefined

[7] Hôpital Cochin,undefined

[8] Faculté de Médecine,undefined

[9] Université Paris-Descartes,undefined

[10] Equipe 16-Immunopathology and Therapeutic Intervention,undefined

[11] Centre de Recherche des Cordeliers,undefined

来源：

Journal of Clinical Immunology | 2007年 / 27卷

关键词：

Intravenous immunoglobulins; autoimmunity; inflammation; immune-modulation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Initially used as a replacement therapy for immunodeficiency diseases, intravenous immunoglobulin (IVIg) is now widely used for a number of autoimmune and inflammatory diseases. Considerable progress has been made in understanding the mechanisms by which IVIg exerts immunomodulatory effects in autoimmune and inflammatory disorders. The mechanisms of action of IVIg are complex, involving modulation of expression and function of Fc receptors, interference with activation of complement and the cytokine network and of idiotype network, regulation of cell growth, and effects on the activation, differentiation, and effector functions of dendritic cells, and T and B cells.

引用

页码：233 / 245

页数：12

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