Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease

被引：0
|
作者：
J. E. Visser
J. H. J. Allum
M. G. Carpenter
R. A. Esselink
J. D. Speelman
G. F. Borm
B. R. Bloem
机构：
[1] Radboud University Nijmegen Medical Centre,Dept. of Neurology (HP 935)
[2] University Hospital Basel,Dept. of Otorhinolaryngology
[3] University of British Columbia,School of Human Kinetics
[4] Radboud University Nijmegen Medical Centre,Dept. of Geriatrics
[5] University Hospital of Amsterdam,Dept. of Neurology, Academic Medical Center
[6] Radboud University Nijmegen Medical Centre,Dept. of Epidemiology and Biostatistics
来源：
Journal of Neurology | 2008年 / 255卷
关键词：
Parkinson's disease; postural instability; subthalamic nucleus; deep brain surgery; posturography;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We examined the effect of bilateral subthalamic nucleus stimulation on levodopa-resistant balance impairment in 14 patients with Parkinson's disease and 18 matched controls. Instability was quantitatively assessed using standardized multidirectional dynamic posturography. Patients were tested after taking a suprathreshold dose of levodopa, both with stimulators turned on and off. Patients with stimulators turned off were more unstable than controls following backward directed perturbations. Overall, patients' instability did not improve with STN stimulation, and considerable inter-individual variability was noted. Of note, marked levodopa- resistant axial motor symptoms before surgery correlated with an adverse treatment effect. We conclude that STN stimulation does not alleviate levodopa-resistant postural instability in Parkinson's disease.
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页码：205 / 210
页数：5
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