The role of pathology in the diagnostics of CUP syndrome [Die Rolle der Pathologie in der Diagnostik des CUP-Syndroms]

被引：0
|
作者：
Stenzinger A. [1 ]
Kriegsmann M. [1 ]
Weichert W. [1 ]
机构：
[1] Institut für Pathologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 224
来源：
Der Radiologe | 2014年 / 54卷 / 2期
关键词：
Classification algorithms; Histomorphology; Immunohistochemistry; Molecular pathology; Multidisciplinary;
D O I：
10.1007/s00117-013-2546-x
中图分类号：
学科分类号：
摘要：
Cancers of unknown primary (CUP) origin account for 2-3% of all malignancies in Germany and represent a heterogeneous, often aggressive and clinically challenging group of tumors with early metastatic dissemination for which a standardized diagnostic work-up initially fails to identify the primary site of origin at the time of diagnosis. This article reviews the options and challenges of tissue-based conventional as well as molecular diagnostic procedures to categorize this heterogeneous group of neoplasms. The role of pathology in the diagnostics of CUP syndrome is described as part of a multidisciplinary effort involving oncologists, surgeons and radiologists with the ultimate goal of assisting clinical reasoning and decision-making. © Springer-Verlag Berlin Heidelberg 2014.
引用
收藏
页码：124 / 133
页数：9
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