Intestinal Patches for Oral Drug Delivery

被引：0
|
作者：
Zancong Shen
Samir Mitragotri
机构：
[1] University of California,Department of Chemical Engineering
来源：
Pharmaceutical Research | 2002年 / 19卷
关键词：
intestinal delivery; mucoadhesive; patch; microspheres;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. Oral route offers an attractive mode of drug administration, although its applications are limited by poor stability of peptides and proteins in the gastrointestinal tract. In this article, we report a novel method based on intestinal patches for oral drug delivery. This method involves the use of millimeter size mucoadhesive patches that adhere to the intestinal wall and direct solute diffusion towards the wall similar to that observed in the case of a transdermal patch.
引用
收藏
页码：391 / 395
页数：4
相关论文
共 50 条
  • [1] Intestinal patches for oral drug delivery
    Shen, ZC
    Mitragotri, S
    PHARMACEUTICAL RESEARCH, 2002, 19 (04) : 391 - 395
  • [2] Oral delivery of macromolecules using intestinal patches: applications for insulin delivery
    Whitehead, K
    Shen, ZC
    Mitragotri, S
    JOURNAL OF CONTROLLED RELEASE, 2004, 98 (01) : 37 - 45
  • [3] Intestinal iontophoresis from mucoadhesive patches: a strategy for oral delivery
    Banerjee, Amrita
    Chen, Renwei
    Arafin, Shamsul
    Mitragotri, Samir
    JOURNAL OF CONTROLLED RELEASE, 2019, 297 : 71 - 78
  • [4] Novel electrospun bioadhesive oral patches for mucosal drug delivery
    Santocildes-Romero, M. E.
    Hadley, L.
    Clitherow, K. H.
    Hansen, J.
    Murdoch, C.
    Colley, H. E.
    Thornhill, M. H.
    Hatton, P. V.
    ORAL DISEASES, 2016, 22 : 11 - 11
  • [5] An overview of intestinal wafers for oral drug delivery
    Kirsch, Kirsten
    Hanke, Ulrike
    Weitschies, Werner
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2017, 114 : 135 - 144
  • [6] Intestinal patch systems for oral drug delivery
    Banerjee, Amrita
    Mitragotri, Samir
    CURRENT OPINION IN PHARMACOLOGY, 2017, 36 : 58 - 65
  • [7] Drug delivery to the intestinal lymph by oral formulations
    Yoshida, Takayuki
    Kojima, Hiroyuki
    Sako, Kazuhiro
    Kondo, Hiromu
    PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2022, 27 (02) : 175 - 189
  • [8] Intestinal patches with an immobilized solid-in-oil formulation for oral protein delivery
    Toorisaka, Eiichi
    Watanabe, Kikumi
    Ono, Hiroshige
    Hirata, Makoto
    Kamiya, Noriho
    Goto, Masahiro
    ACTA BIOMATERIALIA, 2012, 8 (02) : 653 - 658
  • [9] Oral drug delivery utilizing intestinal OATP transporters
    Tamai, Ikumi
    ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 (06) : 508 - 514
  • [10] Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery
    Lu, Rong
    Zhou, Yun
    Ma, Jinqian
    Wang, Yuchen
    Miao, Xiaoqing
    PHARMACEUTICS, 2022, 14 (06)
12345