Wild-type microglia arrest pathology in a mouse model of Rett syndrome

被引：0

作者：

Noël C. Derecki

James C. Cronk

Zhenjie Lu

Eric Xu

Stephen B. G. Abbott

Patrice G. Guyenet

Jonathan Kipnis

机构：

[1] School of Medicine,Department of Neuroscience

[2] University of Virginia,Department of Pharmacology

[3] Graduate Program in Neuroscience,undefined

[4] School of Medicine,undefined

[5] University of Virginia,undefined

[6] Medical Scientist Training Program,undefined

[7] School of Medicine,undefined

[8] University of Virginia,undefined

[9] Undergraduate School of Arts and Sciences,undefined

[10] University of Virginia,undefined

[11] School of Medicine,undefined

[12] University of Virginia,undefined

来源：

Nature | 2012年 / 484卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of disease such as breathing and locomotor abnormalities, implicating microglia in the pathophysiology of Rett syndrome.

引用

页码：105 / 109

页数：4

共 50 条

[1] Wild-type microglia arrest pathology in a mouse model of Rett syndrome
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NATURE, 2012, 484 (7392) : 105 - +
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[3] Wild-type microglia do not reverse pathology in mouse models of Rett syndrome
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[4] Correction: Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome
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