Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33

被引：0

作者：

Iryna Saranchova

Jeffrey Han

Hui Huang

Franz Fenninger

Kyung Bok Choi

Lonna Munro

Cheryl Pfeifer

Ian Welch

Alexander W. Wyatt

Ladan Fazli

Martin E. Gleave

Wilfred A. Jefferies

机构：

[1] The Michael Smith Laboratories,Department of Microbiology & Immunology

[2] University of British Columbia,Department of Animal Care Services

[3] University of British Columbia,Department of Urologic Sciences

[4] 1365 - 2350 Health Sciences Mall,Department of Medical Genetics

[5] Vancouver,Department of Zoology

[6] BC Canada V6T 1Z3,undefined

[7] University of British Columbia,undefined

[8] 4145 Wesbrook Mall,undefined

[9] Vancouver BC Canada V6T 1W5,undefined

[10] University of British Columbia Gordon & Leslie Diamond Health Care Centre,undefined

[11] Level 6,undefined

[12] 2775 Laurel Street,undefined

[13] Vancouver,undefined

[14] BC Canada V5Z 1M9,undefined

[15] The Vancouver Prostate Centre,undefined

[16] University of British Columbia 2660 Oak Street,undefined

[17] Vancouver,undefined

[18] BC Canada V6H 3Z6,undefined

[19] University of British Columbia 1364 - 2350 Health Sciences Mall,undefined

[20] Vancouver,undefined

[21] BC Canada V6T 1Z3,undefined

[22] University of British Columbia 4200 - 6270 University Blvd,undefined

[23] Vancouver,undefined

[24] BC Canada V6T 1Z4,undefined

[25] Centre for Blood Research at the University of British Columbia 4th Floor - 2350 Health Sciences Mall,undefined

[26] Vancouver,undefined

[27] BC Canada V6T 1Z3,undefined

[28] Djavad Mowafaghian Centre for Brain Health at the University of British Columbia 2215 Wesbrook Mall,undefined

[29] Vancouver BC Canada V6T 1Z3.,undefined

来源：

Scientific Reports | / 6卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A new paradigm for understanding immune-surveillance and immune escape in cancer is described here. Metastatic carcinomas express reduced levels of IL-33 and diminished levels of antigen processing machinery (APM), compared to syngeneic primary tumours. Complementation of IL-33 expression in metastatic tumours upregulates APM expression and functionality of major histocompatibility complex (MHC)-molecules, resulting in reduced tumour growth rates and a lower frequency of circulating tumour cells. Parallel studies in humans demonstrate that low tumour expression of IL-33 is an immune biomarker associated with recurrent prostate and kidney renal clear cell carcinomas. Thus, IL-33 has a significant role in cancer immune-surveillance against primary tumours, which is lost during the metastatic transition that actuates immune escape in cancer.

引用

共 13 条

[1] Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33
Saranchova, Iryna
Han, Jeffrey
Huang, Hui
Fenninger, Franz
Choi, Kyung Bok
Munro, Lonna
Pfeifer, Cheryl
Welch, Ian
Wyatt, Alexander W.
Fazli, Ladan
Gleave, Martin E.
Jefferies, Wilfred A.
SCIENTIFIC REPORTS, 2016, 6
[2] Tumour immune escape by the loss of homeostatic chemokine expression
Pivarcsi, A.
Mueller, A.
Hippe, A.
Rieker, J.
van Lierop, A.
Steinhoff, M.
Seeliger, S.
Kubitza, R.
Pippirs, U.
Meller, S.
Gerber, P. A.
Liersch, R.
Bnemann, E.
Sonkoly, E.
Wiesner, U.
Hoffmann, T. K.
Schneider, L.
Piekorz, R.
Enderlein, E.
Reifenberger, J.
Rohr, U.
Haas, R.
Boukamp, P.
Haase, I.
Nuernberg, B.
Ruzicka, T.
Zlotnik, A.
Homey, B.
EXPERIMENTAL DERMATOLOGY, 2008, 17 (03) : 282 - 282
[3] Expression of Interleukin-33 by resident and immune cells in the skin of patients with atopic dermatitis
Smith, L.
Moran, B.
Rea, H.
Raverdeau, M.
McDonald, I.
Mills, K.
Steinhoff, M.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2016, 136 (09) : S207 - S207
[4] Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer
Akimoto, M.
Hayashi, J-I
Nakae, S.
Saito, H.
Takenaga, K.
CELL DEATH & DISEASE, 2016, 7 : e2057 - e2057
[5] Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer
M Akimoto
J-I Hayashi
S Nakae
H Saito
K Takenaga
Cell Death & Disease, 2016, 7 : e2057 - e2057
[6] Dermal, but not Epidermal, Immune Reaction in Cutaneous Spiruroid Larva Migrans: Involvement of Basophils in Dermal Interleukin-33 and Thymic Stromal Lymphopoietin Expression
Hashimoto, Takashi
Okuno, Satoshi
Okuzawa, Manami
Satoh, Takahiro
ACTA DERMATO-VENEREOLOGICA, 2022, 102
[7] Interleukin-33 acts as a pro-inflammatory cytokine and modulates its receptor gene expression in highly metastatic human pancreatic carcinoma cells
Schmieder, Annett
Multhoff, Gabriele
Radons, Juergen
CYTOKINE, 2012, 60 (02) : 514 - 521
[8] Loss of IFN-γ pathway gene expression in tumor cells as mechanism of immune escape of colorectal carcinoma
Britzen-Laurent, Nathalie
Straube, Julia
Waldner, Maximilian
Becker, Christoph
Croner, Roland
Pilarsky, Christian
Merkel, Susanne
Stuerzl, Michael
CANCER RESEARCH, 2018, 78 (13)
[9] Molecular mechanism of PMA-induced up-regulation of interleukin-33 gene expression in Swiss 3T3 cells
Yamamoto, Sayaka
Mizuguchi, Hiroyuki
Matsui, Kouki
Esu, Takako
Kitamura, Yoshiaki
Nabe, Takeshi
Takeda, Noriaki
Fukui, Hiroyuki
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124 : 96P - 96P
[10] Loss of chemokine CXCL14 expression in oral squamous cell carcinoma (SCC) as a new mechanism of tumor escape from immune recognition.
Kogan, D.
Collins, B.
Watchmaker, P.
Perez, L.
Tourkova, I.
Shurin, G. V.
Shurin, M. R.
JOURNAL OF DENTAL RESEARCH, 2003, 82 : B40 - B40

← 1 2 →