The rifampicin drug delivery system based on phospholipid nanoparticles

被引：1
|
作者：
Sanzhakov M.A. [1 ]
Prozorovskyi V.N. [1 ]
Ipatova O.M. [1 ]
Tikhonova E.G. [1 ]
Medvedeva N.V. [1 ]
Torkhovskaya T.I. [1 ]
机构：
[1] Orekhovich Institute of Biomedical Chemistry, Moscow 119121
来源：
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | 2014年 / 8卷 / 2期
关键词：
Bioavailability; Nanoparticles; Oleate; Phospholipids; Rifampicin; Tuberculosis treatment;
D O I：
10.1134/S1990750814020127
中图分类号：
学科分类号：
摘要：
Low bioavailability of rifampicin, one of the main antituberculous agents, stimulates searches of its new optimized formulations. The present study has shown a possibility of rifampicin incorporation into nanoparticles from plant phosphatidylcholine (diameter of 20-30 nm). Addition of sodium oleate to the phospholipid system caused a 2-fold increase in the percent of rifampicin incorporation. The maximal concentration of rifampicin assayed in plasma samples by LC/MS was observed 1 h after oral administration to rats (6 mg/kg) and represented 0.5 and 4.2 μg/mL for free rifampicin and rifampicin incorporated in the phospholipids-oleate nanoparticles, respectively. These levels were maintained for more than 2 h of the experiment. High rifampicin bioavailability in the oleate containing phospholipid nanosystem suggests its prospects for practical use. © Pleiades Publishing, Ltd., 2014.
引用
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页码：177 / 180
页数：3
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