Target class drug discovery

被引：0

作者：

Kimberly D Barnash

Lindsey I James

Stephen V Frye

机构：

[1] Center for Integrative Chemical Biology and Drug Discovery,Division of Chemical Biology and Medicinal Chemistry

[2] UNC Eshelman School of Pharmacy,undefined

[3] University of North Carolina at Chapel Hill,undefined

来源：

Nature Chemical Biology | 2017年 / 13卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complementary approach that has higher quality outcomes in early discovery efforts.

引用

页码：1053 / 1056

页数：3

共 50 条

[1] Target class drug discovery
Barnash, Kimberly D.
James, Lindsey I.
Frye, Stephen V.
NATURE CHEMICAL BIOLOGY, 2017, 13 (10) : 1053 - 1056
[2] Protein methyltransferases as a target class for drug discovery
Robert A. Copeland
Michael E. Solomon
Victoria M. Richon
Nature Reviews Drug Discovery, 2009, 8 : 724 - 732
[3] Protein methyltransferases as a target class for drug discovery
Copeland, Robert A.
Solomon, Michael E.
Richon, Victoria M.
NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (09) : 724 - 732
[4] Protein methyltransferases as a target class for cancer drug discovery
Copeland, Robert A.
CANCER RESEARCH, 2011, 71
[5] Vignettes in kinase inhibitor drug discovery: Evolution of a drug target class
Barrish, Joel C.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
[6] Proteomics for drug target discovery
Gottfries, J
Sjögren, M
Holmberg, B
Rosengren, L
Davidsson, P
Blennow, K
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2004, 73 (01) : 47 - 53
[7] The adipocyte as a drug discovery target
Nawrocki, AR
Scherer, PE
DRUG DISCOVERY TODAY, 2005, 10 (18) : 1219 - 1230
[8] Target selection in drug discovery
Knowles, J
Gromo, G
NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (01) : 63 - 69
[9] Genomics in target and drug discovery
van Duin, M
Woolson, H
Mallinson, D
Black, D
BIOCHEMICAL SOCIETY TRANSACTIONS, 2003, 31 : 429 - 432
[10] Molecular Target Drug Discovery
Kimura, Fumihiko
INTERNAL MEDICINE, 2007, 46 (02) : 87 - 89

← 1 2 3 4 5 →