Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities

被引：0
|
作者：
Siyi Li
Chibuzo Sampson
Changhao Liu
Hai-long Piao
Hong-Xu Liu
机构：
[1] Cancer Research Institute,Department of Thoracic Surgery
[2] Cancer Hospital of China Medical University,Dalian Institute of Chemical Physics
[3] Liaoning Cancer Hospital & Institute,Department of Biochemistry & Molecular Biology, School of Life Sciences
[4] Chinese Academy of Sciences,undefined
[5] China Medical University,undefined
来源：
Cell Communication and Signaling | / 21卷
关键词：
Integrin; Tumorigenesis; Bidirectional signaling mechanisms; Integrin-targeting drugs;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Integrins are transmembrane receptors that possess distinct ligand-binding specificities in the extracellular domain and signaling properties in the cytoplasmic domain. While most integrins have a short cytoplasmic tail, integrin β4 has a long cytoplasmic tail that can indirectly interact with the actin cytoskeleton. Additionally, 'inside-out' signals can induce integrins to adopt a high-affinity extended conformation for their appropriate ligands. These properties enable integrins to transmit bidirectional cellular signals, making it a critical regulator of various biological processes.
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