Controlled DNA Delivery Systems

被引：0
|
作者：
Dan Luo
Kim Woodrow-Mumford
Nadya Belcheva
W. Mark Saltzman
机构：
[1] Cornell University,School of Chemical Engineering
来源：
Pharmaceutical Research | 1999年 / 16卷
关键词：
DNA; controlled release; microsphere; EVAc; PLGA; PLA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. Genes are of increasing interest as pharmaceuticals, but current methods for long-term gene delivery are inadequate. Controlled release systems using biocompatible and/or biodegradable polymers offer many advantages over conventional gene delivery approaches. We have characterized systems for controlled delivery of DNA from implantable polymer matrices (EVAc: poly (ethylene-co-vinyl acetate)) and injectable microspheres (PLGA and PLA: poly (D, L-lactide-co-glycolide) copolymer and poly (L-lactide), respectively).
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页码：1300 / 1308
页数：8
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