Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

被引：0

作者：

Narin Hengrung

Kamel El Omari

Itziar Serna Martin

Frank T. Vreede

Stephen Cusack

Robert P. Rambo

Clemens Vonrhein

Gérard Bricogne

David I. Stuart

Jonathan M. Grimes

Ervin Fodor

机构：

[1] Sir William Dunn School of Pathology,Division of Structural Biology

[2] University of Oxford,undefined

[3] Henry Wellcome Building for Genomic Medicine,undefined

[4] University of Oxford,undefined

[5] European Molecular Biology Laboratory,undefined

[6] Grenoble Outstation and University Grenoble Alpes-Centre National de la Recherche Scientifique-EMBL Unit of Virus Host-Cell Interactions,undefined

[7] Diamond Light Source Ltd,undefined

[8] Harwell Science & Innovation Campus,undefined

[9] Global Phasing Ltd,undefined

来源：

Nature | 2015年 / 527卷

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学科分类号：

摘要：

The X-ray crystal structure of influenza C virus polymerase, captured in a closed, pre-activation confirmation, is solved at 3.9 Å resolution; comparison with previous RNA-bound structures reveals large conformational changes associated with RNA binding and activation, and illustrates the notable flexibility of the influenza virus RNA polymerase.

引用

页码：114 / 117

页数：3

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