Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trial

被引:0
|
作者
Antoine Roquilly
Bruno Francois
Olivier Huet
Yoann Launey
Sigismond Lasocki
Emmanuel Weiss
Melanie Petrier
Yannick Hourmant
Marwan Bouras
Karim Lakhal
Cecilia Le Bel
Delphine Flattres Duchaussoy
Laia Fernández-Barat
Adrian Ceccato
Laurent Flet
Alexandra Jobert
Jeremie Poschmann
Veronique Sebille
Fanny Feuillet
Despoina Koulenti
Antoni Torres
机构
[1] Nantes Université,ICU Department and Inserm CIC 1435 & UMR 1092
[2] CHU Nantes,Département d’anesthésie réanimation et medecine peri
[3] INSERM,operatoire, CHRU de Brest
[4] Anesthesie Réanimation,Department of Anaesthesia, Critical Care and Perioperative Medicine
[5] CIC 1413,Department of Anesthesiology and Critical Care Medicine
[6] Nantes Université,Department of Anesthesiology and Critical Care
[7] CHU Nantes,2nd Critical Care Department
[8] INSERM,Faculty of Medicine, UQ Centre for Clinical Research
[9] Center for Research in Transplantation and Translational Immunology,undefined
[10] UMR 1064,undefined
[11] University Hospital of Limoges,undefined
[12] Université de Bretagne Occidentale,undefined
[13] Univ Rennes,undefined
[14] CHU Rennes,undefined
[15] University Hospital of Angers,undefined
[16] Université Paris Cité,undefined
[17] INSERM UMR_S1149,undefined
[18] and AP-HP Nord,undefined
[19] Hôpital Beaujon,undefined
[20] CELLEX research laboratories,undefined
[21] CibeRes (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias,undefined
[22] 06/06/0028),undefined
[23] Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS),undefined
[24] Servei de Pneumologia,undefined
[25] Hospital Clinic,undefined
[26] Barcelona,undefined
[27] Universitat de Barcelona,undefined
[28] CIBERES,undefined
[29] Icrea,undefined
[30] IDIBAPS,undefined
[31] Nantes Université,undefined
[32] CHU Nantes,undefined
[33] Pharmacie,undefined
[34] Nantes Université,undefined
[35] CHU Nantes,undefined
[36] DRI,undefined
[37] Département promotion,undefined
[38] cellule vigilances recherche,undefined
[39] Nantes Université,undefined
[40] CHU Nantes,undefined
[41] DRI,undefined
[42] Plateforme de Méthodologie et de Biostatistique,undefined
[43] Nantes Université,undefined
[44] Université de Tours,undefined
[45] CHU Nantes,undefined
[46] CHU Tours,undefined
[47] INSERM,undefined
[48] SPHERE U1246,undefined
[49] Attikon University Hospital,undefined
[50] The University of Queensland,undefined
来源
Intensive Care Medicine | 2023年 / 49卷
关键词
Intensive care; Hospital-acquired pneumonia; Interferon-gamma; Immunotherapy; Immunosuppression;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:530 / 544
页数:14
相关论文
共 50 条
  • [1] Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trial
    Roquilly, Antoine
    Francois, Bruno
    Huet, Olivier
    Launey, Yoann
    Lasocki, Sigismond
    Weiss, Emmanuel
    Petrier, Melanie
    Hourmant, Yannick
    Bouras, Marwan
    Lakhal, Karim
    Le Bel, Cecilia
    Duchaussoy, Delphine Flattres
    Fernandez-Barat, Laia
    Ceccato, Adrian
    Flet, Laurent
    Jobert, Alexandra
    Poschmann, Jeremie
    Sebille, Veronique
    Feuillet, Fanny
    Koulenti, Despoina
    Torres, Antoni
    INTENSIVE CARE MEDICINE, 2023, 49 (05) : 530 - 544
  • [2] PREVENTION OF HOSPITAL-ACQUIRED PNEUMONIA IN CRITICALLY ILL PATIENTS
    HAMER, DH
    BARZA, M
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (05) : 931 - 938
  • [3] A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis
    Raghu, G
    Brown, KK
    Bradford, WZ
    Starko, K
    Noble, PW
    Schwartz, DA
    King, TE
    Adlakha, A
    Tarczynski, S
    Ainslie, G
    Kalam, R
    Bai, T
    Truchan, H
    Baughman, R
    Wingst, D
    Bhorade, S
    Norwick, L
    Brown, KK
    Kervitsky, D
    Calhoun, W
    DiNella, L
    Chan, C
    Jamieson, L
    Chan, K
    Turpen, T
    Chapman, J
    Slattery, S
    Chen, L
    Turner, J
    Clark, M
    Sanders, R
    Crain, M
    Pate, D
    Davis, G
    Lynn, M
    Dhar, A
    Hrytsytk, M
    Drent, M
    Horr, ET
    du Bois, R
    Goh, N
    Egan, J
    Anthony, N
    Enelow, R
    Haram, T
    Ettinger, N
    Merli, S
    Frost, A
    Holy, R
    Glassberg, M
    NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (02): : 125 - 133
  • [4] Hospital-acquired bacterial pneumonia in critically ill patients: from research to clinical practice
    Kouroupis, Pompeo Costantino
    O'Rourke, Niall
    Kelly, Sinead
    McKittrick, Myles
    Noppe, Elne
    Reyes, Luis F.
    Rodriguez, Alejandro
    Martin-Loeches, Ignacio
    EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2024, 22 (06) : 423 - 433
  • [5] Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial
    King, Talmadge E., Jr.
    Albera, Carlo
    Bradford, Williamson Z.
    Costabel, Ulrich
    Hormel, Phil
    Lancaster, Lisa
    Noble, Paul W.
    Sahn, Steven A.
    Szwarcberg, Javier
    Thomeer, Michiel
    Valeyre, Dominique
    du Bois, Roland M.
    LANCET, 2009, 374 (9685): : 222 - 228
  • [6] Hospitalization of patients with idiopathic pulmonary fibrosis (IPF) in a phase 3, randomized, double-blind, placebo-controlled trial of interferon gamma-1B (IFN-γ1B)
    Bradford, WZ
    Starko, K
    Noble, PW
    CHEST, 2003, 124 (04) : 193S - 193S
  • [7] XueBiJing Injection Versus Placebo for Critically Ill Patients With Severe Community-Acquired Pneumonia: A Randomized Controlled Trial
    Song, Yuanlin
    Yao, Chen
    Yao, Yongming
    Han, Hui
    Zhao, Xiaodong
    Yu, Kaijiang
    Liu, Luyi
    Xu, Ying
    Liu, Zhongmin
    Zhou, Qingshan
    Wang, Ying
    Ma, Zhuang
    Zheng, Youguang
    Wu, Dawei
    Tang, Zhongzhi
    Zhang, Minzhou
    Pan, Shuming
    Chai, Yanfen
    Song, Yan
    Zhang, Jian
    Pan, Lei
    Liu, Yi
    Yu, He
    Yu, Xuezhong
    Zhang, Hong
    Wang, Xiaoge
    Du, Zhaohui
    Wan, Xianyao
    Tang, Yijun
    Tian, Yingping
    Zhu, Yimin
    Wang, Hongliang
    Yan, Xiaoyan
    Liu, Zhi
    Zhang, Boli
    Zhong, Nanshan
    Shang, Hongcai
    Bai, Chunxue
    CRITICAL CARE MEDICINE, 2019, 47 (09) : E735 - E743
  • [8] A Randomized Placebo-Controlled Trial on the Use of Arginine Supplementation for the Prevention of Nosocomial Infection in Critically Ill Patients.
    Salise, R.
    Tuazon, A.
    PEDIATRIC PULMONOLOGY, 2018, 53 : S142 - S143
  • [9] Correction of Vitamin D Deficiency in Critically Ill Patients: A Randomized Placebo-Controlled Trial
    Amrein, Karin
    Schnedl, Christian
    Holl, Alexander
    Riedl, Regina
    Christopher, Kenneth B.
    Urbanic-Purkart, Tadeja
    Berghold, Andrea
    Pieber, Thomas R.
    Pachler, Christoph
    Waltensdorfer, Andreas
    Muench, Andreas
    Stojakovic, Tatjana
    Bisping, Egbert
    Toller, Wolfgang
    Dobnig, Harald
    ENDOCRINE REVIEWS, 2014, 35 (03)
  • [10] Effect of Early Administration of Vitamin D on Clinical Outcome in Critically Ill Sepsis Patients: Randomized Placebo-controlled Trial
    Bhattacharyya, Amrita
    Subramaniam, Rajeshwari
    Baidya, Dalim K.
    Aggarwal, Praveen
    Wig, Naveet
    INDIAN JOURNAL OF CRITICAL CARE MEDICINE, 2021, 25 (10) : 1145 - 1152