8-Alkyl[1,2,4]Triazolo[5,1-b]Purines

被引：0
|
作者：
K. V. Savateev
E. N. Ulomsky
S. S. Borisov
E. K. Voinkov
V. V. Fedotov
V. L. Rusinov
机构：
[1] Ural Federal University named after the First President of Russia B. N. Yeltsin,
来源：
Chemistry of Heterocyclic Compounds | 2014年 / 50卷
关键词：
anomalous nucleosides; nitrogen heterocycles; purines; triazolopyrimidines; chlorodes-oxygenation; nitro group reduction;
D O I：
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学科分类号：
摘要：
A novel method has been developed for the synthesis of 8-alkyl[1, 2, 4]triazolo[5,1-b]purines from 6-nitro[1,2,4]triazolo[1,5-a]pyrimidin-7-ones via successive phosphoryl chloride-mediated chloro-desoxygenation, aminodehalogenation, and reduction to give 7-alkylamino-6-amino[1,2,4]triazolo-[1,5-a]pyrimidines. The latter can be cyclized in the presence of formic acid.
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页码：880 / 887
页数：7
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