▴ 131I tositumomab is a radiolabelled murine anti-CD20 monoclonal antibody that binds specifically to the CD20 antigen on normal and malignant B lymphocytes. It has antitumour activity as a result of emission of beta particles, and activation of antibody-dependent cellular and complement-mediated cytotoxicity.
机构:
St Bartholomews Hosp, Dept Med Oncol, Cand Res Uk Med Oncol Unit, London, EnglandSt Bartholomews Hosp, Dept Med Oncol, Cand Res Uk Med Oncol Unit, London, England
Davies, AJ
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,
2004,
48
(04):
: 305
-
316
机构:
Univ Michigan Hlth Syst, Div Neuroradiol, Dept Radiol, Ann Arbor, MI 48109 USAUniv Michigan Hlth Syst, Div Neuroradiol, Dept Radiol, Ann Arbor, MI 48109 USA
Srinivasan, A.
Mukherji, S. K.
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机构:
Univ Michigan Hlth Syst, Div Neuroradiol, Dept Radiol, Ann Arbor, MI 48109 USAUniv Michigan Hlth Syst, Div Neuroradiol, Dept Radiol, Ann Arbor, MI 48109 USA