Crystal structures of agonist-bound human cannabinoid receptor CB1

被引：0

作者：

Tian Hua

Kiran Vemuri

Spyros P. Nikas

Robert B. Laprairie

Yiran Wu

Lu Qu

Mengchen Pu

Anisha Korde

Shan Jiang

Jo-Hao Ho

Gye Won Han

Kang Ding

Xuanxuan Li

Haiguang Liu

Michael A. Hanson

Suwen Zhao

Laura M. Bohn

Alexandros Makriyannis

Raymond C. Stevens

Zhi-Jie Liu

机构：

[1] iHuman Institute,Department of Chemistry and Chemical Biology

[2] ShanghaiTech University,Departments of Molecular Medicine and Neuroscience

[3] National Laboratory of Biomacromolecules,Departments of Biological Sciences and Chemistry

[4] Institute of Biophysics,Complex Systems Division

[5] Chinese Academy of Sciences,undefined

[6] University of Chinese Academy of Sciences,undefined

[7] Center for Drug Discovery,undefined

[8] Department of Pharmaceutical Sciences,undefined

[9] Northeastern University,undefined

[10] The Scripps Research Institute,undefined

[11] Bridge Institute,undefined

[12] University of Southern California,undefined

[13] School of Life Science and Technology,undefined

[14] ShanghaiTech University,undefined

[15] Beijing Computational Science Research Center,undefined

[16] GPCR Consortium,undefined

来源：

Nature | 2017年 / 547卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Crystal structures of the human cannabinoid receptor 1 (CB1) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor activation, and this flexibility may be a common feature among other G-protein-coupled receptors.

引用

页码：468 / 471

页数：3

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