Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection

被引：0

作者：

Rebekah M. Dedrick

Krista G. Freeman

Jan A. Nguyen

Asli Bahadirli-Talbott

Bailey E. Smith

Andrew E. Wu

Aaron S. Ong

Cheng Ting Lin

Lisa C. Ruppel

Nicole M. Parrish

Graham F. Hatfull

Keira A. Cohen

机构：

[1] University of Pittsburgh,Biological Sciences

[2] Johns Hopkins University School of Medicine,Division of Pulmonary and Critical Care Medicine

[3] Johns Hopkins University School of Medicine,Department of Radiology

[4] Johns Hopkins University School of Medicine,Investigational Pharmacy

[5] Johns Hopkins University School of Medicine,Department of Pathology

来源：

Nature Medicine | 2021年 / 27卷

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摘要：

An 81-year-old immunocompetent patient with bronchiectasis and refractory Mycobacterium abscessus lung disease was treated for 6 months with a three-phage cocktail active against the strain. In this case study of phage to lower infectious burden, intravenous administration was safe and reduced the M. abscessus sputum load tenfold within one month. However, after two months, M. abscessus counts increased as the patient mounted a robust IgM- and IgG-mediated neutralizing antibody response to the phages, which was associated with limited therapeutic efficacy.

引用

页码：1357 / 1361

页数：4

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