Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

被引：0

作者：

Chen Zhao

Alan Chen

Catriona H. Jamieson

Mark Fereshteh

Annelie Abrahamsson

Jordan Blum

Hyog Young Kwon

Jynho Kim

John P. Chute

David Rizzieri

Michael Munchhof

Todd VanArsdale

Philip A. Beachy

Tannishtha Reya

机构：

[1] Department of Pharmacology and Cancer Biology,Department of Medicine, Division of Cellular Therapy

[2] ,Department of Medicine

[3] Duke University Medical Center,Department of Developmental Biology Institute of Stem Cell Biology and Regenerative Medicine

[4] Durham,Division of Medicinal Chemistry

[5] North Carolina 27710,Division of Oncology

[6] USA,undefined

[7] Stem Cell Research Program,undefined

[8] Moores UCSD Cancer Center La Jolla,undefined

[9] California 92093,undefined

[10] USA,undefined

[11] Howard Hughes Medical Institute,undefined

[12] Stanford University Medical Center,undefined

[13] Stanford,undefined

[14] California 94305,undefined

[15] USA,undefined

[16] Pfizer Laboratories,undefined

[17] Groton,undefined

[18] Connecticut 06340,undefined

[19] USA,undefined

[20] Pfizer Laboratories,undefined

[21] La Jolla,undefined

[22] California 92121,undefined

[23] USA,undefined

来源：

Nature | 2009年 / 458卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Hedgehog signalling has been implicated in a number of cancers. It is now shown to be important in chronic myeloid leukaemias (CML) where it acts to maintain leukaemia stem cells, by regulating the expression of Numb. Importantly, CML stem cells can be depleted when Hedgehog signalling is inhibited, including cells that are resistant to the drug imatinib that is used to treat CML.

引用

页码：776 / 779

页数：3

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