Starlike vs. Classic Macromolecular Prodrugs: Two Different Antibody-Targeted HPMA Copolymers of Doxorubicin Studied in Vitro and in Vivo as Potential Anticancer Drugs

被引：0

作者：

Markéta Jelínková

Jiří Strohalm

Tomáš Etrych

Karel Ulbrich

Blanka Říhová

机构：

[1] Institute of Microbiology,Academy of Sciences of the Czech Republic

[2] Institute of Macromolecular Chemistry,Academy of Sciences of the Czech Republic

来源：

Pharmaceutical Research | 2003年 / 20卷

关键词：

antibody-targeted doxorubicin; HPMA copolymer; polymer drug carrier; starlike conjugate; drug delivery;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. Two different monoclonal antibody-targeted HPMA copolymer-doxorubicin conjugates, classic and starlike, were synthesized to be used for site-specific cancer therapy. The anti-mouse Thy-1.2 (IgG3) and two anti-human CD71/A (IgG1) and CD71/B (IgG2a) monoclonal antibodies were used as targeting structures.

引用

页码：1558 / 1564

页数：6