Designer T cells - New possibilities for immunotherapy of cancer [Designer-T-Zellen – neue Möglichkeiten für die Immuntherapie von Krebs]

被引：0
|
作者：
Leisegang M. [1 ]
Uckert W. [1 ]
机构：
[1] Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Straße 10, Berlin
来源：
BIOspektrum | 2015年 / 21卷 / 4期
关键词：
D O I：
10.1007/s12268-015-0594-7
中图分类号：
学科分类号：
摘要：
The genetic engineering of T cells with T cell or chimeric antigen receptors generates tumor-specific designer T cells for immunotherapy of cancer. The clinical use of these cells requires (1) careful selection of the target antigen that should be tumor-specific, (2) an optimized configuration of therapeutic genes, to generate T cells of high functional activity and (3) efficient vector systems that allow the generation of sufficient numbers of engineered T cells within a short period of time. © 2015, Springer-Verlag Berlin Heidelberg.
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页码：402 / 405
页数：3
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