Decomposition of reactive oxygen species by copper(II) bis(1-pyrazolyl)methane complexes

被引:0
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作者
Igor Schepetkin
Andrei Potapov
Andrei Khlebnikov
Elena Korotkova
Anna Lukina
Galina Malovichko
Lilia Kirpotina
Mark T. Quinn
机构
[1] Montana State University,Department of Veterinary Molecular Biology
[2] Altai State Technical University,Department of Chemistry
[3] Tomsk Polytechnic University,Department of Chemical Technology
[4] Montana State University,Department of Physics
关键词
Pyrazole derivatives; Copper complexes; Superoxide dismutase mimetics; Reactive oxygen species; Peroxynitrite;
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摘要
Two bis(1-pyrazolyl)alkane ligands, bis(3,5-dimethyl-1-pyrazolyl)methane and bis(4-iodo-3,5-dimethyl-1-pyrazolyl)methane, and their copper(II) complexes, bis(3,5-dimethyl-1-pyrazolyl)methanedinitratocopper(II) [CuL1(NO3)2] and bis(4-iodo-3,5-dimethyl-1-pyrazolyl)methanedinitratocopper(II) [CuL2(NO3)2]·2H2O, were prepared. Physiochemical properties of the copper(II) complexes were studied by spectroscopic (UV–vis, IR, EPR) techniques and cyclic voltammetry. Spectroscopic analysis revealed a 1:1 stoichiometry of ligand:copper(II) ion and a bindentate coordination mode for the nitrate ions in both of the complexes. According to experimental and theoretical ab initio data, the copper(II) ion is located in an octahedral hexacoordinated environment. Both complexes were able to catalyze the dismutation of superoxide anion (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\text{O}}^{{\bullet - }}_{{\text{2}}} $$\end{document}) (pH 7.5) and decomposition of H2O2 (pH 7.5) and peroxynitrite (pH 10.9). In addition, both complexes exhibited superoxide dismutase (SOD) like activity toward extracellular and intracellular reactive oxygen species produced by activated human neutrophils in whole blood. Thus, these complexes represent useful SOD mimetics with a broad range of antioxidant activity toward a variety of reactive oxidants.
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页码:499 / 513
页数:14
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