Facile synthesis of 2′,5′-dideoxy-, 2′,3′-dideoxy- and 3′-deoxy-1, N6-ethenoadenosine nucleosides

被引：0
|
作者：
Chae W.-G. [1 ]
机构：
[1] Department of Biochemistry, School of Medicine, Catholic University of Taegu-Hyosung
来源：
Biotechnology and Bioprocess Engineering | 1999年 / 4卷 / 1期
关键词：
2′; 3′-dideoxy-1; N[!sup]6[!/sup]-ethenoadenosine; 5′-dideoxy-1; N[!sup]6[!/sup]-; ethenoadenosine; 3′-deoxy-1; Nucleoside phosphorylase;
D O I：
10.1007/BF02931907
中图分类号：
学科分类号：
摘要：
Facile synthetic methods of 2′,5′-dideoxy-, 2′,3′-dideoxy- and 3′-deoxy-1,N6-ethenoadenosine nucleosides by either an enzymatic dideoxyribosyl transfer reaction or a simple chemical reaction were proposed. The synthetic products were isolated and purified by preparative HPLC and their structures were confirmed by 1H NMR (500 MHz) and FAB-MS including high resolution mass measurement. These modified nucleoside analogs have not been reported yet. Therefore, these modified nucleoside analogs are of potential value to be studied further for biological activity such as anticancer or antiviral.
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页码：17 / 20
页数：3
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