The structure of a giant ubiquitin E3 ligase sheds light on its activation in a substrate-dependent manner and shows how a single E3 enzyme uses distinct recognition modules to confer substrate specificity.
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Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA
Galligan, Jeffrey T.
Martinez-Noel, Gustavo
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Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA
Martinez-Noel, Gustavo
Arndt, Verena
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Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA
Arndt, Verena
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Hayes, Sebastian
Chittenden, Thomas W.
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Harvard Univ, Sch Med, Res Comp Grp, Boston, MA 02115 USA
Complex Biol Syst Alliance, N Andover, MA 01845 USAHarvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA
Chittenden, Thomas W.
Harper, J. Wade
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Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA
Harper, J. Wade
Howley, Peter M.
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Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA