T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis

被引：0

作者：

Bradley N Martin

Chenhui Wang

Cun-jin Zhang

Zizhen Kang

Muhammet Fatih Gulen

Jarod A Zepp

Junjie Zhao

Guanglin Bian

Jeong-su Do

Booki Min

Paul G Pavicic

Caroline El-Sanadi

Paul L Fox

Aoi Akitsu

Yoichiro Iwakura

Anasuya Sarkar

Mark D Wewers

William J Kaiser

Edward S Mocarski

Marc E Rothenberg

Amy G Hise

George R Dubyak

Richard M Ransohoff

Xiaoxia Li

机构：

[1] Cleveland Clinic Lerner Research Institute,Department of Immunology

[2] Case Western Reserve University School of Medicine,Department of Pathology

[3] Key Laboratory of Molecular Biophysics of the Ministry of Education,Department of Neurology

[4] College of Life Science and Technology,Department of Immunology

[5] Huazhong University of Science and Technology,Department of Physiology and Biophysics

[6] Tianjin Neurological Institute,Department of Cellular and Molecular Medicine

[7] Tianjin Medical University General Hospital,Department of Microbiology and Immunology

[8] Tianjin Neurological Institute,Division of Allergy and Immunology

[9] Tianjin Medical University General Hospital,Department of Neurosciences

[10] Shanghai Institute of Immunology,undefined

[11] Shanghai Jiaotong University School of Medicine,undefined

[12] Case Western Reserve University School of Medicine,undefined

[13] Cleveland Clinic Lerner Research Institute,undefined

[14] Research Institute for Biomedical Sciences,undefined

[15] Tokyo University of Science,undefined

[16] Yamazaki,undefined

[17] Davis Heart and Lung Research Institute,undefined

[18] Ohio State University College of Medicine,undefined

[19] Emory Vaccine Center,undefined

[20] Cincinnati Children's Hospital Medical Center,undefined

[21] Center for Global Health and Diseases,undefined

[22] Case Western Reserve University,undefined

[23] Cleveland Clinic Lerner Research Institute,undefined

[24] Present address: Biogen Idec,undefined

[25] Cambridge,undefined

[26] Massachusetts,undefined

[27] USA.,undefined

来源：

Nature Immunology | 2016年 / 17卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Inflammasome activation triggers the release of active interleukin 1β (IL-1β). Li and colleagues show that TH17 cells can release IL-1β upon T cell antigen receptor and ATP stimulation via an ASC–NLPR3–caspase-8 axis, thereby contributing to neuroinflammation.

引用

页码：583 / 592

页数：9

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