A comparison of two collapsing methods in different approaches

被引：2
|
作者：
Carmen Dering
Arne Schillert
Inke R König
Andreas Ziegler
机构：
[1] Universität zu Lübeck,Institut für Medizinische Biometrie und Statistik
[2] Universitätsklinikum Schleswig-Holstein,Zentrum für Klinische Studien
[3] Universität zu Lübeck,undefined
来源：
BMC Proceedings | / 8卷 / Suppl 1期
关键词：
Minor Allele Frequency; Principal Component Score; Genetic Analysis Workshop; Functional Principal Component Analysis; Gene KRT23;
D O I：
10.1186/1753-6561-8-S1-S8
中图分类号：
学科分类号：
摘要：
Sequencing technologies have enabled the investigation of whole genomes of many individuals in parallel. Studies have shown that the joint consideration of multiple rare variants may explain a relevant proportion of the genetic basis for disease so that grouping of rare variants, termed collapsing, can enrich the association signal.
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