Assessing risk of stroke after idiopathic sudden sensorineural hearing loss using data from general practice

被引:0
|
作者
Oussoren, Fieke K. [1 ,2 ]
Schermer, Tjard R. [2 ,3 ]
Horn, Leonie R. [3 ]
van Leeuwen, Roeland B. [2 ]
Bruintjes, Tjasse D. [1 ,2 ]
机构
[1] Leiden Univ, Dept Otorhinolaryngol, Med Ctr, POB 9600, NL-2300 RC Leiden, Netherlands
[2] Gelre Hosp, Apeldoorn Dizziness Ctr, Apeldoorn, Netherlands
[3] Radboud Univ Nijmegen, Radboudumc Res Inst Med Innovat, Dept Primary & Community Care, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands
来源
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词
Idiopathic sudden sensorineural hearing loss; Stroke; General practice; Cardiovascular risk;
D O I
10.1038/s41598-024-59934-3
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The cause of sudden sensorineural hearing loss (SSNHL) remains unknown in a significant number of cases, but vascular involvement in its pathophysiology has been proposed. Our study aimed to assess the incidence of stroke following idiopathic SSNHL (iSSNHL) and to evaluate associated cardiovascular risk factors and comorbidities. We extracted electronic medical record data from iSSNHL patients aged >= 50 years retrospectively from 84 general practices. Patients were matched for age, sex and general practice in a 1:4 ratio to controls. Primary outcome was the 5-years stroke risk following iSSNHL diagnosis. 480 iSSNHL cases could be matched to 1911 controls. The hazard ratio for iSSNHL compared with controls was 1.25 (95%CI 0.50-3.27; P = 0.646) for CVA (cerebrovascular accident) alone and 0.92 (95% CI 0.50-1.71; P = 0.804) for CVA and TIA (transient ischemic attack) combined. The hazard ratio for the interaction term between iSSNHL and age >= 60 years was 4.84 (95% CI 1.02-23.05; P = 0.048) for CVA and TIA combined. Patients with iSSNHL used antihypertensives and beta-blocking agents more frequently than controls (P = 0.006 and P = 0.022, respectively). In conclusion, no overall significant difference in the risk of stroke was observed, but the hazard ratio for stroke increased in iSSNHL patients aged 60 and older, suggesting potential vascular involvement in older subjects presenting with sudden sensorineural hearing loss.
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页数:9
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