Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

被引：902

作者：

Gupta, RA ^{[1
]}

DuBois, RN

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Cell Biol, Nashville, TN 37232 USA

[3] Vet Affairs Med Ctr, Nashville, TN 37232 USA

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 01期

关键词：

D O I：

10.1038/35094017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Population-based studies have established that long-term intake of non-steroidal antiinflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of cyclooxygenase (COX), reduces the relative risk for developing colorectal cancer These studies led to the identification of a molecular target, COX-2, that is involved in tumour promotion during colorectal cancer progression. Recent studies in humans indicate that therapy with specific COX-2 inhibitors might be an effective approach to colorectal cancer prevention and treatment.

引用

页码：11 / 21

页数：11

共 130 条

[1]

Adam L, 2001, CANCER RES, V61, P81

[2]

Bamba H, 1999, INT J CANCER, V83, P470, DOI 10.1002/(SICI)1097-0215(19991112)83:4<470::AID-IJC6>3.3.CO

[3]

2-6

[4] Sulindac suppresses tumorigenesis in the Min mouse [J].

BeazerBarclay, Y ;

Levy, DB ;

Moser, AR ;

Dove, WF ;

Hamilton, SR ;

Vogelstein, B ;

Kinzler, KW .

CARCINOGENESIS, 1996, 17 (08) :1757-1760

[5] Nuclear localization of prostaglandin E2 receptors [J].

Bhattacharya, M ;

Peri, KG ;

Almazan, G ;

Ribeiro-Da-Silva, A ;

Shichi, H ;

Durocher, Y ;

Abramovitz, M ;

Hou, X ;

Varma, DR ;

Chemtob, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15792-15797

[6]

Boolbol SK, 1996, CANCER RES, V56, P2556

[7] COX-2 expression is induced by UVB exposure in human skin: Implications for the development of skin cancer [J].

Buckman, SY ;

Gresham, A ;

Hale, P ;

Hruza, G ;

Anast, J ;

Masferrer, J ;

Pentland, AP .

CARCINOGENESIS, 1998, 19 (05) :723-729

[8]

Castelao JE, 2000, BRIT J CANCER, V82, P1364

[9]

Chan G, 1999, CANCER RES, V59, P991

[10] Localization of cyclooxygenase-2 in human sporadic colorectal adenomas [J].

Chapple, KS ;

Cartwright, EJ ;

Hawcroft, G ;

Tisbury, A ;

Bonifer, C ;

Scott, N ;

Windsor, ACJ ;

Guillou, PJ ;

Markham, AF ;

Coletta, PL ;

Hull, MA .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (02) :545-553

← 1 2 3 4 5 6 7 8 9 10 →