The Effect of Media Composition, pH, and Formulation Excipients on the In Vitro Lipolysis of Self-Emulsifying Drug Delivery Systems (SEDDS)

被引：9
|
作者：
Ali, Hazem [1 ]
Siddiqui, Akhtar [1 ]
Nazzal, Sami [1 ]
机构：
[1] Univ Louisiana Monroe, Coll Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 71209 USA
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2010年 / 31卷 / 02期
关键词：
Digestion; emulsion; fatty acids; lipolysis; SEDDS; WATER-SOLUBLE DRUGS; SOLUBILIZATION BEHAVIOR; ORAL BIOAVAILABILITY; LIPID FORMULATIONS; PANCREATIC LIPASE; LIPOPHILIC DRUGS; VIVO PERFORMANCE; FAT DIGESTION; DISSOLUTION; ABSORPTION;
D O I：
10.1080/01932690903110566
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The objective of the present work was to investigate the effects of pH, ions, and excipients on the in vitro lipolysis of self-emulsifying drug delivery systems (SEDDS). Studies were performed in bio-relevant media using a pH stat autotitrator for analysis. The results demonstrated that alkaline media were essential for lipolysis, which was enhanced by divalent CaCl2 ions and medium chain glycerides. Monovalent NaCl and the hydrophile-lipophile balance (HLB) of the surfactant had insignificant effect on lipolysis. Consequently, it was concluded that the activity of lipase, at an optimum pH of 6.5, is the predominant factors for digestion of SEDDS.
引用
收藏
页码：226 / 232
页数：7
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