Optimization of visual training for full recovery from severe amblyopia in adults

被引：22

作者：

Eaton, Nicolette C. ^{[1
]}

Sheehan, Hanna Marie ^{[1
]}

Quinlan, Elizabeth M. ^{[1
,2
]}

机构：

[1] Univ Maryland, Dept Biol, College Pk, MD 20742 USA

[2] Univ Maryland, Neurosci & Cognit Sci Program, College Pk, MD 20742 USA

来源：

LEARNING & MEMORY | 2016年 / 23卷 / 02期

关键词：

OCULAR DOMINANCE PLASTICITY; LONG-TERM POTENTIATION; MONOCULAR DEPRIVATION; ENVIRONMENTAL ENRICHMENT; NMDA RECEPTORS; EXPERIENCE; CORTEX; PERIOD; TRANSMISSION; VISION;

D O I：

10.1101/lm.040295.115

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The severe amblyopia induced by chronic monocular deprivation is highly resistant to reversal in adulthood. Here we use a rodent model to show that recovery from deprivation amblyopia can be achieved in adults by a two-step sequence, involving enhancement of synaptic plasticity in the visual cortex by dark exposure followed immediately by visual training. The perceptual learning induced by visual training contributes to the recovery of vision and can be optimized to drive full recovery of visual acuity in severely amblyopic adults.

引用

页码：99 / 103

页数：5

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