Solubility of Racemic Potassium 2-(1-Hydroxypentyl)-benzoate in Six Solvents at 298.15-333.15 K

被引:2
|
作者
Zhao, Huan [1 ]
Meng, Zihui [1 ]
Xue, Min [1 ]
Wang, Peng [1 ]
Xu, Zhibin [1 ]
机构
[1] Beijing Inst Technol, Sch Chem & Environm Engn, Beijing 100081, Peoples R China
关键词
FOCAL CEREBRAL-ISCHEMIA; ETHYL-ACETATE; PLUS WATER; MIXTURES; RATS; ACID; ETHANOL; TOLUENE; BRAIN;
D O I
10.1021/ie5028149
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
The solubility of racemic potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB) in methanol, ethanol, n-propanol, isopropyl alcohol, ethyl acetate, and acetone from 298.15 to 333.15 K was measured by an equilibrium method. The solubility data of dl-PHPB in six different solvents was correlated by the modified Apelblat equation. The correlation coefficients were observed in the range of 0.993 to 0.998, indicating a good fit. The results showed that the mole fraction solubility of dl-PHPB in methanol (6.22 X 10(-2)), ethanol (2.58 X 10(-2)), n-propanol (2.39 X 10(-2)), and isopropyl alcohol (6.72 X 10(-3)) was significantly higher than in acetone (2.58 X 10(-4)) and ethyl acetate (8.02 X 10(-5)) at 298.15 K. The experiment data would be useful for optimizing purification and recrystallization processes of dl-PHPB in industry.
引用
收藏
页码:14892 / 14895
页数:4
相关论文
共 32 条
  • [1] Toxicokinetics and toxicity of potassium 2-(1-hydroxypentyl)-benzoate in beagle dogs
    Li, Jiang
    Wang, Xiao-Liang
    Wang, Ai-Ping
    Xu, Shao-Feng
    Jin, Hong-Tao
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2017, 19 (04) : 388 - 401
  • [2] POTASSIUM 2-(1-HYDROXYPENTYL)-BENZOATE IMPROVES LEARNING AND MEMORY DEFICITS IN CHRONIC CEREBRAL HYPOPERFUSED RATS
    Zhao, W.
    Wang, X.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2014, 115 : 208 - 208
  • [3] Potassium 2-(1-hydroxypentyl)-benzoate improves depressive-like behaviors in rat model
    Hao Ma
    Weiping Wang
    Shaofeng Xu
    Ling Wang
    Xiaoliang Wang
    ActaPharmaceuticaSinicaB, 2018, 8 (06) : 881 - 888
  • [4] Potassium 2-(1-hydroxypentyl)-benzoate improves depressive-like behaviors in rat model
    Ma, Hao
    Wang, Weiping
    Xu, Shaofeng
    Wang, Ling
    Wang, Xiaoliang
    ACTA PHARMACEUTICA SINICA B, 2018, 8 (06) : 881 - 888
  • [5] Solubility of Bioactive Compound Hesperidin in Six Pure Solvents at (298.15 to 333.15) K
    Anwer, Md Khalid
    Al-Shdefat, Ramadan
    Jamil, Shahid
    Alam, Prawez
    Abdel-Kader, Maged S.
    Shakeel, Faiyaz
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2014, 59 (06): : 2065 - 2069
  • [6] Potassium 2-(1-hydroxypentyl)-benzoate improves learning and memory deficits in chronic cerebral hypoperfused rats
    Zhao, Wanhong
    Xu, Shaofeng
    Peng, Ying
    Ji, Xincai
    Cao, Dongxu
    Li, Jiang
    Liu, Bin
    Shi, Qiaoqiao
    Wang, Ling
    Wang, Xiaoliang
    NEUROSCIENCE LETTERS, 2013, 541 : 155 - 160
  • [7] Effects of 2-(1-hydroxypentyl)-benzoate on platelet aggregation and thrombus formation in rats
    Zhang, Y
    Wang, L
    Zhang, LY
    Wang, XL
    DRUG DEVELOPMENT RESEARCH, 2004, 63 (04) : 174 - 180
  • [8] The attenuation effect of potassium 2-(1-hydroxypentyl)-benzoate in a mouse model of diabetes-associated cognitive decline: The protein expression in the brain
    Yu, Wenwen
    Yin, Huajing
    Sun, Yingni
    Shi, Si
    Li, Jiang
    Wang, Xiaoliang
    CNS NEUROSCIENCE & THERAPEUTICS, 2022, 28 (07) : 1108 - 1123
  • [9] Potassium 2-(1-Hydroxypentyl)-Benzoate Improves Memory Deficits and Attenuates Amyloid and τ Pathologies in a Mouse Model of Alzheimer's Diseases
    Peng, Ying
    Hu, Yanli
    Xu, Shaofeng
    Rong, Xianfang
    Li, Jiang
    Li, PingPing
    Wang, Ling
    Yang, Jinghua
    Wang, Xiaoliang
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2014, 350 (02): : 361 - 374
  • [10] Potassium 2-(1-hydroxypentyl)-benzoate attenuated hydrogen peroxide-induced apoptosis in neuroblastoma SK-N-SH cells
    Hu, Yanli
    Peng, Ying
    Long, Yan
    Xu, Shaofeng
    Feng, Nan
    Wang, Ling
    Wang, Xiaoliang
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 680 (1-3) : 49 - 54