Membrane Protein Clusters at Nanoscale Resolution: More Than Pretty Pictures

被引：50

作者：

Lang, Thorsten ^{[1
]}

Rizzoli, Silvio O. ^{[2
]}

机构：

[1] Univ Bonn, LIMES Inst, Lab Membrane Biochem, D-5300 Bonn, Germany

[2] DFG Ctr Mol Physiol Brain, European Neurosci Inst, STED Microscopy Synapt Funct, Gottingen, Germany

来源：

PHYSIOLOGY | 2010年 / 25卷 / 02期

基金：

欧洲研究理事会;

关键词：

FLUORESCENCE MICROSCOPY; STED MICROSCOPY; RECONSTRUCTION; DYNAMICS;

D O I：

10.1152/physiol.00044.2009

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Fluorescence microscopy is powerful for analyzing the composition and dynamics of cellular elements, but studying precise molecule patterns is precluded due to diffraction limited resolution. This barrier has been lifted now through several superresolution microscopy techniques. They revealed that proteins assemble in defined groups (clusters). A new challenge thus appears for the biologist: to find out whether clusters are molecular machines, stabilizers of defined protein conformations, or simply protein reservoirs.

引用

页码：116 / 124

页数：9

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