Pharmacokinetic Evaluation of Raft Forming Tablet for Controlled Delivery of Pantoprazole Sodium Sesquihydrate

Alginate-pectin polymeric raft forming tablets were developed with the aim of controlled delivery of pantoprazole sodium sesquihydrate (PSS). The pharmacokinetic of PSS was evaluated using non-compartmental and one compartmental approach after oral administration of raft forming tablets. The R9 formulation and Zopent 40 mg tablet was selected as test and reference formulations respectively. Twelve albino rabbits were selected and divided into 2 groups using Latin square cross over design and blood samples were collected for 24 h. Different pharmacokinetic parameters of the test and reference formulations were calculated using Kinetica 4.4.1. Average values of C-max and t(max) were 46.305 +/- 0.507 mu g/mL and 4 +/- 1.398 h for the reference formulation but C-max and t(max) of test formulation was 46.089 +/- 0.567 mu g/mL and 8 +/- 2.345 h, respectively. AUC((0-t)) of reference and test formulations were 363.705 +/- 2.017 mu g x h/mL and 513.072 +/- 3.467 mu g x h/mL respectively. AUC((0-infinity)) of the reference and test formulations were 393.122 +/-.408 mu g x h/mL and 549.443 +/-.678 mu g x h/mL respectively. AUMC of the reference and test formulations were 3761.022 +/- 3.902 mu g x h/mL and 5966.536 +/- 2.896 mu g x h/mL. MRT of reference and test formulation was 9.567 +/- 4.289 h and 10.589 +/- 3.896 h, respectively. The p value of T-max and C-max were 0.0001 and 0.0024 respectively indicates the results are statistically significant.