Evolutionary consideration on 5-aminolevulinate synthase in nature

被引:19
|
作者
OhHama, T
机构
[1] Research Institute of Evolutionary Biology, Tokyo 158
来源
ORIGINS OF LIFE AND EVOLUTION OF THE BIOSPHERE | 1997年 / 27卷 / 04期
关键词
D O I
10.1023/A:1006583601341
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
5-Aminolevulinic acid (ALA), a universal precursor of tetrapyrrole compounds can be synthesized by two pathways: the C-5 (glutamate) pathway and ALA synthase. From the phylogenetic distribution it is shown that distribution of ALA synthase is restricted to the alpha subclass of purple bacteria in prokaryotes, and further distributed to mitochondria of eukaryotes. The monophyletic origin of bacterial and eukaryotic ALA synthase is shown by sequence analysis of the enzyme. Evolution of ALA synthase in the alpha subclass of purple bacteria is discussed in relation to the energy-generating and biosynthetic devices in subclasses of this bacteria.
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页码:405 / 412
页数:8
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