Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection

被引：5

作者：

Price, Jennifer C. ^{[1
]}

Seaberg, Eric C. ^{[2
]}

Phair, John P. ^{[3
]}

Witt, Mallory D. ^{[4
]}

Koletar, Susan L. ^{[5
]}

Thio, Chloe L. ^{[6
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Gastroenterol & Hepatol, 513 Parnassus Ave,S-357, San Francisco, CA 94143 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Northwestern Univ, Dept Med, Div Infect Dis, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles Biomed Res Inst,Harbor UCLA, Torrance, CA USA

[5] Ohio State Univ, Dept Med, Div Infect Dis, Columbus, OH 43210 USA

[6] Johns Hopkins Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 03期

基金：

美国国家卫生研究院;

关键词：

HIV; HBV; HCV; antiviral therapy; liver; hepatitis; APRI; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C VIRUS; MULTICENTER AIDS COHORT; PLATELET RATIO INDEX; FIBROSIS PROGRESSION; MONOINFECTED PATIENTS; COINFECTED PATIENTS; NONINVASIVE INDEX; HUMAN HEPATOCYTES; VIRAL-HEPATITIS;

D O I：

10.1097/QAI.0000000000000981

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre-and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.

引用

页码：319 / 323

页数：5

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