The Role of Fungus in Chronic Rhinosinusitis

被引：17

作者：

Orlandi, Richard R. ^{[1
]}

Marple, Bradley F. ^{[2
]}

机构：

[1] Univ Utah, Div Otolaryngol Head & Neck Surg, Salt Lake City, UT 84132 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Otolaryngol Head & Neck Surg, Dallas, TX 75390 USA

来源：

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2010年 / 43卷 / 03期

关键词：

Chronic rhinosinusitis; Fungus; Alternaria; Amphotericin B; Etiology; Pathogenesis; TOPICAL AMPHOTERICIN-B; NASAL POLYPS; DOUBLE-BLIND; ANTIFUNGAL TREATMENT; IRRIGATION; ORGANISMS; MARKERS; PROTEIN; CELLS; TRIAL;

D O I：

10.1016/j.otc.2010.02.011

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Fungus has been cited as an etiologic factor (the etiologic factor?) in chronic rhinosinusitis (CRS), and a vigorous debate has ensued. Initial reports of in vitro observations promoted fungus as a potential origin of CRS, yet subsequent clinical trials of topical and systemic antifungal treatments have failed to demonstrate meaningful efficacy. More recent laboratory work has cast significant doubt on the universality of the fungal hypothesis by failing to replicate one of its basic science underpinnings. Combined with clinical data about antifungal therapy's ineffectiveness, these findings appear to tip the scales against fungus as the universal etiology of CRS.

引用

页码：531 / +

页数：8

共 50 条

[1] Etiology of chronic rhinosinusitis: The role of fungus
Hamilos, D
Lund, VJ
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2004, 113 (05): : 27 - 31
[2] The role of fungus in the pathogenesis of chronic rhinosinusitis
Challapalli, Sai D.
McKee, Sean
Luong, Amber U.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY, 2022, 30 (01): : 58 - 62
[3] The role of fungus in the etiology of chronic rhinosinusitis and nasal polyposis
Sapci, T.
Fethallah, B.
Karavus, A.
Mercangoez, E.
Usta, C.
Yazici, S.
Akbulut, U. G.
Bozkurt, S.
TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY, 2006, 44 (01) : 18 - 24
[4] Role of fungus in chronic rhinosinusitis: Proceedings of a consensus meeting - Conclusion
Kennedy, DW
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2004, 113 (05): : 32 - 32
[5] Role of fungus in chronic rhinosinusitis: Proceedings of a consensus meeting - Introduction
Kennedy, DW
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2004, 113 (05): : 2 - 2
[6] Fungus and chronic rhinosinusitis: Weighing the evidence
Orlandi, Richard R.
Marple, Bradley F.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2010, 143 (05) : 611 - 613
[7] Fungus: A Role in Pathophysiology of Chronic Rhinosinusitis, Disease Modifier, A Treatment Target, or No Role at All?
Fokkens, Wytske J.
Ebbens, Fenna
van Drunen, Cornelis M.
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2009, 29 (04) : 677 - +
[8] Chrysosporium: An Uncommon Fungus in Chronic Rhinosinusitis
Kamath, Panduranga M.
Prasad, Vishnu
Shenoy, Vijendra S.
Mukundan, Aswin
Shenoy, Suchithra
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2015, 9 (03) : MD01 - MD02
[9] Fungus and chronic rhinosinusitis: From bench to clinical understanding
Lanza, Donald C.
Dhong, Hun-Jong
Tantilipikorn, Pongsakorn
Tanabodee, Jirayu
Nadel, Douglas M.
Kennedy, David W.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2006, 115 (09): : 27 - 34
[10] Immunologic response to fungus is not universally associated with chronic rhinosinusitis
Ponikau, Jens U.
Sherris, David A.
Kern, Eugene B.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2010, 143 (05) : 607 - 610

← 1 2 3 4 5 →