Application of a new electrometric approach to study interaction between biological molecules

被引：1
|
作者：
Starodub, NF [1 ]
Goraychuk, IP [1 ]
Starodub, VM [1 ]
Il'chenko, VV [1 ]
Kuznetsov, GV [1 ]
机构：
[1] Natl Acad Sci Ukraine, AV Palladin Biochem Inst, Kiev, Ukraine
来源：
DESIGN, TEST, INTEGRATION, AND PACKAGING OF MEMS/MOEMS, PROCEEDINGS | 2000年 / 4019卷
关键词：
ultra-thin metal film; layer of the porous silicon; current-voltage characteristics; surface-barrier structures (SBS); proteins; myoglobin; antibodies;
D O I：
10.1117/12.382319
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In the paper the results about changes of the current-voltage characteristics (I-V) of the surface-barrier structures (SBS) after the deposition of myoglobin (Mb) and its specific monoclonal antibodies (AT) are presented. It was shown that the SBS structures with ultra-thin metal film (Ni-Si) or with ultra-thin layer of the porous silicon (PorSi-Si) are sensitive to the presence of the protein or its specific immune complex on their surfaces. The response of the system depended on the conditions of the specific complex formation. The characteristic optimum of the thickness of Ni film or the layer of the porous silicon was revealed when the changes of the I-V characteristics had a maximum level.
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页码：506 / 515
页数：10
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