Synthesis of cyclic proline-containing peptides via ring-closing metathesis

被引：49

作者：

Harris, PWR ^{[1
]}

Brimble, MA ^{[1
]}

Gluckman, PD ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, NeuronZ Med Chem Grp, Auckland, New Zealand

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 11期

关键词：

D O I：

10.1021/ol034370e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several dienes embedded in di- and tripeptides which incorporate proline have been prepared and subjected to ring-closing metathesis. Bicyclic peptides of well-defined amide geometry and of varying ring sizes were prepared. Several limitations of the cyclization step were revealed.

引用

页码：1847 / 1850

页数：4

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